253519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3287638..3288437 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NR351_RS16070 Protein ID WP_000347273.1
Coordinates 3287973..3288437 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NR351_RS16065 Protein ID WP_001307405.1
Coordinates 3287638..3287973 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS16050 (3283423) 3283423..3284193 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NR351_RS16055 (3284209) 3284209..3285543 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NR351_RS16060 (3285918) 3285918..3287489 + 1572 WP_001273753.1 galactarate dehydratase -
NR351_RS16065 (3287638) 3287638..3287973 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NR351_RS16070 (3287973) 3287973..3288437 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NR351_RS16075 (3288492) 3288492..3289301 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NR351_RS16080 (3289550) 3289550..3290830 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NR351_RS16085 (3290853) 3290853..3291326 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NR351_RS16090 (3291337) 3291337..3291708 + 372 Protein_3142 PTS sugar transporter subunit IIC -
NR351_RS16095 (3291704) 3291704..3292261 + 558 Protein_3143 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3278490..3288437 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T253519 WP_000347273.1 NZ_CP102378:3287973-3288437 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT253519 WP_001307405.1 NZ_CP102378:3287638-3287973 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References