278174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 608532..609331 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX09_RS02995 Protein ID WP_000347273.1
Coordinates 608532..608996 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX09_RS03000 Protein ID WP_001307405.1
Coordinates 608996..609331 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS02965 (603533) 603533..603967 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX09_RS02970 (603985) 603985..604863 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX09_RS02975 (604853) 604853..605632 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX09_RS02980 (605643) 605643..606116 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX09_RS02985 (606139) 606139..607419 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX09_RS02990 (607668) 607668..608477 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX09_RS02995 (608532) 608532..608996 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX09_RS03000 (608996) 608996..609331 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX09_RS03005 (609480) 609480..611051 - 1572 WP_001273753.1 galactarate dehydratase -
QDX09_RS03010 (611426) 611426..612760 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX09_RS03015 (612776) 612776..613546 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 608532..620205 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278174 WP_000347273.1 NZ_CP122880:c608996-608532 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278174 WP_001307405.1 NZ_CP122880:c609331-608996 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References