137445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2003605..2004404 Replicon chromosome
Accession NZ_CP043185
Organism Escherichia coli O16:H48 strain PG20180171

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag FYA18_RS09725 Protein ID WP_000347273.1
Coordinates 2003940..2004404 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag FYA18_RS09720 Protein ID WP_001307405.1
Coordinates 2003605..2003940 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA18_RS09705 1999390..2000160 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
FYA18_RS09710 2000176..2001510 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
FYA18_RS09715 2001885..2003456 + 1572 WP_001273753.1 galactarate dehydratase -
FYA18_RS09720 2003605..2003940 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FYA18_RS09725 2003940..2004404 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FYA18_RS09730 2004459..2005268 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FYA18_RS09735 2005517..2006797 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
FYA18_RS09740 2006820..2007293 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
FYA18_RS09745 2007304..2007675 + 372 Protein_1903 PTS sugar transporter subunit IIC -
FYA18_RS09750 2007671..2008228 + 558 Protein_1904 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1994457..2004404 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T137445 WP_000347273.1 NZ_CP043185:2003940-2004404 [Escherichia coli O16:H48]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T137445 NZ_CP056742:c1447447-1447127 [Enterobacter hormaechei]
ATGCAAATCTCAACTGTACCGGCCACGGTGCCGGCTTCATCACGCCTGTCGCCCGTGCAGGTGTGGCAGCAATTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTCACACTCAACGACACGCCATTCCACGATGATTCAGCCATTCAGGAACATATTG
AAGCGGGAATAACACTGGCTGATGCGGTGAATTTCCTGGTGGAACGCTATGAACTGGTGCGTATTGACCGTAAGGGATTC
AGCTGGCAGGAGCAGACACCGTTCCTGACTGCTACCGATATTCACAGAGCAAAGCGTGCTACCGGGCTGATGAGTACATA
A

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT137445 WP_001307405.1 NZ_CP043185:2003605-2003940 [Escherichia coli O16:H48]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT137445 NZ_CP056742:c1447849-1447514 [Enterobacter hormaechei]
ATGAACAAAGACACTACCCAAATCTGGGGTCTTAAACGAGAGATTACACCGTGCTTCGGATCGCGGATGGTGCAGGAAGG
TCATCGTCTGCATTTTCTGGCGGACCGGGCAGGGTTCACCGGTTCATTTAGCGAGATGCAGGTCCGACATCTGGATGAAG
CCTTCCCGCATTTTGTCGCGCATCTGGAGCTGATGTTGCTCTCTGGCGAACTGAATCCCCGCTATGCACACAGCGTTACG
CTGTACCGTAACGAACTGACCTGTGAAGCTGATACGCTGGGCAGTTATGGGTATGTATATATCGCAATTTATCCCTCAAA
TCTGGTTAAAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References