269472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604304..605103 Replicon chromosome
Accession NZ_CP116929
Organism Escherichia coli strain MLI105

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag NL421_RS03100 Protein ID WP_000347275.1
Coordinates 604304..604768 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NL421_RS03105 Protein ID WP_001307405.1
Coordinates 604768..605103 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL421_RS03070 (599305) 599305..599739 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NL421_RS03075 (599757) 599757..600635 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NL421_RS03080 (600625) 600625..601404 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
NL421_RS03085 (601415) 601415..601888 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NL421_RS03090 (601911) 601911..603191 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NL421_RS03095 (603440) 603440..604249 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NL421_RS03100 (604304) 604304..604768 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NL421_RS03105 (604768) 604768..605103 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NL421_RS03110 (605252) 605252..606823 - 1572 WP_001273752.1 galactarate dehydratase -
NL421_RS03115 (607198) 607198..608532 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NL421_RS03120 (608548) 608548..609318 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 604304..615978 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T269472 WP_000347275.1 NZ_CP116929:c604768-604304 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT269472 WP_001307405.1 NZ_CP116929:c605103-604768 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References