174093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3271560..3272359 Replicon chromosome
Accession NZ_CP062249
Organism Escherichia coli strain AML002_ev01

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag IHN46_RS15880 Protein ID WP_000347273.1
Coordinates 3271895..3272359 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IHN46_RS15875 Protein ID WP_001307405.1
Coordinates 3271560..3271895 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN46_RS15860 3267345..3268115 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
IHN46_RS15865 3268131..3269465 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IHN46_RS15870 3269840..3271411 + 1572 WP_001273753.1 galactarate dehydratase -
IHN46_RS15875 3271560..3271895 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IHN46_RS15880 3271895..3272359 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IHN46_RS15885 3272414..3273223 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IHN46_RS15890 3273472..3274752 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
IHN46_RS15895 3274775..3275248 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
IHN46_RS15900 3275259..3275630 + 372 Protein_3105 PTS sugar transporter subunit IIC -
IHN46_RS15905 3275626..3276183 + 558 Protein_3106 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3262412..3272359 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T174093 WP_000347273.1 NZ_CP062249:3271895-3272359 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T174093 NZ_CP080548:856830-857147 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT174093 WP_001307405.1 NZ_CP062249:3271560-3271895 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT174093 NZ_CP080548:856618-856827 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References