190312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1901781..1902580 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JSW75_RS09190 Protein ID WP_000347273.1
Coordinates 1902116..1902580 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JSW75_RS09185 Protein ID WP_001307405.1
Coordinates 1901781..1902116 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS09170 (1897566) 1897566..1898336 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
JSW75_RS09175 (1898352) 1898352..1899686 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JSW75_RS09180 (1900061) 1900061..1901632 + 1572 WP_001273753.1 galactarate dehydratase -
JSW75_RS09185 (1901781) 1901781..1902116 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JSW75_RS09190 (1902116) 1902116..1902580 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JSW75_RS09195 (1902635) 1902635..1903444 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JSW75_RS09200 (1903693) 1903693..1904973 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JSW75_RS09205 (1904996) 1904996..1905469 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JSW75_RS09210 (1905480) 1905480..1905851 + 372 Protein_1803 PTS sugar transporter subunit IIC -
JSW75_RS09215 (1905847) 1905847..1906404 + 558 Protein_1804 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1892633..1902580 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T190312 WP_000347273.1 NZ_CP069386:1902116-1902580 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T190312 NZ_CP091240:2727444-2727641 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT190312 WP_001307405.1 NZ_CP069386:1901781-1902116 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT190312 NZ_CP091240:c2727387-2727324 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References