277893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 642896..643695 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX84_RS03115 Protein ID WP_000347273.1
Coordinates 642896..643360 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX84_RS03120 Protein ID WP_001307405.1
Coordinates 643360..643695 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS03085 (637897) 637897..638331 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX84_RS03090 (638349) 638349..639227 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX84_RS03095 (639217) 639217..639996 - 780 WP_282835138.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX84_RS03100 (640007) 640007..640480 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX84_RS03105 (640503) 640503..641783 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX84_RS03110 (642032) 642032..642841 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX84_RS03115 (642896) 642896..643360 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX84_RS03120 (643360) 643360..643695 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX84_RS03125 (643844) 643844..645415 - 1572 WP_001273753.1 galactarate dehydratase -
QDX84_RS03130 (645790) 645790..647124 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX84_RS03135 (647140) 647140..647910 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 642896..654569 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277893 WP_000347273.1 NZ_CP122801:c643360-642896 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277893 WP_001307405.1 NZ_CP122801:c643695-643360 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References