262706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3374112..3374911 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OLR74_RS16625 Protein ID WP_000347273.1
Coordinates 3374447..3374911 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OLR74_RS16620 Protein ID WP_001307405.1
Coordinates 3374112..3374447 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS16605 (3369897) 3369897..3370667 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
OLR74_RS16610 (3370683) 3370683..3372017 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OLR74_RS16615 (3372392) 3372392..3373963 + 1572 WP_001273753.1 galactarate dehydratase -
OLR74_RS16620 (3374112) 3374112..3374447 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OLR74_RS16625 (3374447) 3374447..3374911 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OLR74_RS16630 (3374966) 3374966..3375775 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OLR74_RS16635 (3376024) 3376024..3377304 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OLR74_RS16640 (3377327) 3377327..3377800 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
OLR74_RS16645 (3377811) 3377811..3378182 + 372 Protein_3252 PTS sugar transporter subunit IIC -
OLR74_RS16650 (3378178) 3378178..3378735 + 558 Protein_3253 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3364964..3374911 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T262706 WP_000347273.1 NZ_CP110016:3374447-3374911 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT262706 WP_001307405.1 NZ_CP110016:3374112-3374447 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References