284430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2896497..2897296 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QSI84_RS14230 Protein ID WP_000347273.1
Coordinates 2896832..2897296 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QSI84_RS14225 Protein ID WP_001307405.1
Coordinates 2896497..2896832 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS14210 (2892282) 2892282..2893052 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
QSI84_RS14215 (2893068) 2893068..2894402 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QSI84_RS14220 (2894777) 2894777..2896348 + 1572 WP_001273753.1 galactarate dehydratase -
QSI84_RS14225 (2896497) 2896497..2896832 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QSI84_RS14230 (2896832) 2896832..2897296 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QSI84_RS14235 (2897351) 2897351..2898160 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QSI84_RS14240 (2898409) 2898409..2899689 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QSI84_RS14245 (2899712) 2899712..2900185 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QSI84_RS14250 (2900196) 2900196..2900567 + 372 Protein_2781 PTS sugar transporter subunit IIC -
QSI84_RS14255 (2900563) 2900563..2901120 + 558 Protein_2782 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2887349..2897296 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T284430 WP_000347273.1 NZ_CP128218:2896832-2897296 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284430 WP_001307405.1 NZ_CP128218:2896497-2896832 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References