277993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 664099..664898 Replicon chromosome
Accession NZ_CP122832
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDY27_RS03195 Protein ID WP_000347273.1
Coordinates 664099..664563 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY27_RS03200 Protein ID WP_001307405.1
Coordinates 664563..664898 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS03165 (659100) 659100..659534 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY27_RS03170 (659552) 659552..660430 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY27_RS03175 (660420) 660420..661199 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY27_RS03180 (661210) 661210..661683 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY27_RS03185 (661706) 661706..662986 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY27_RS03190 (663235) 663235..664044 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDY27_RS03195 (664099) 664099..664563 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY27_RS03200 (664563) 664563..664898 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY27_RS03205 (665047) 665047..666618 - 1572 WP_094336530.1 galactarate dehydratase -
QDY27_RS03210 (666993) 666993..668327 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDY27_RS03215 (668343) 668343..669113 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 664099..675771 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277993 WP_000347273.1 NZ_CP122832:c664563-664099 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277993 WP_001307405.1 NZ_CP122832:c664898-664563 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References