277716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 622569..623368 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX02_RS03055 Protein ID WP_000347273.1
Coordinates 622569..623033 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX02_RS03060 Protein ID WP_001307405.1
Coordinates 623033..623368 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS03025 (617570) 617570..618004 - 435 WP_000948814.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX02_RS03030 (618022) 618022..618900 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX02_RS03035 (618890) 618890..619669 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX02_RS03040 (619680) 619680..620153 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX02_RS03045 (620176) 620176..621456 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX02_RS03050 (621705) 621705..622514 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX02_RS03055 (622569) 622569..623033 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX02_RS03060 (623033) 623033..623368 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX02_RS03065 (623517) 623517..625088 - 1572 WP_001273754.1 galactarate dehydratase -
QDX02_RS03070 (625463) 625463..626797 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX02_RS03075 (626813) 626813..627583 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 622569..634130 11561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277716 WP_000347273.1 NZ_CP122712:c623033-622569 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277716 WP_001307405.1 NZ_CP122712:c623368-623033 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References