278670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 659145..659944 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag QET41_RS03220 Protein ID WP_000347275.1
Coordinates 659145..659609 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QET41_RS03225 Protein ID WP_001307405.1
Coordinates 659609..659944 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS03190 (654146) 654146..654580 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QET41_RS03195 (654598) 654598..655476 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QET41_RS03200 (655466) 655466..656245 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QET41_RS03205 (656256) 656256..656729 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QET41_RS03210 (656752) 656752..658032 - 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
QET41_RS03215 (658281) 658281..659090 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QET41_RS03220 (659145) 659145..659609 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QET41_RS03225 (659609) 659609..659944 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QET41_RS03230 (660093) 660093..661664 - 1572 WP_001273752.1 galactarate dehydratase -
QET41_RS03235 (662039) 662039..663373 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QET41_RS03240 (663389) 663389..664159 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 659145..670819 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T278670 WP_000347275.1 NZ_CP123231:c659609-659145 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278670 WP_001307405.1 NZ_CP123231:c659944-659609 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References