92406

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 526638..527437 Replicon chromosome
Accession NZ_CP025913
Organism Escherichia coli strain 203740

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag CXW72_RS02575 Protein ID WP_000347273.1
Coordinates 526973..527437 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag CXW72_RS02570 Protein ID WP_005762317.1
Coordinates 526638..526973 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW72_RS02555 522438..523208 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
CXW72_RS02560 523224..524543 - 1320 WP_001735763.1 galactarate/glucarate/glycerate transporter GarP -
CXW72_RS02565 524918..526489 + 1572 WP_001273753.1 galactarate dehydratase -
CXW72_RS02570 526638..526973 + 336 WP_005762317.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CXW72_RS02575 526973..527437 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CXW72_RS02580 527492..528301 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
CXW72_RS02585 528550..529830 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
CXW72_RS02590 529853..530326 + 474 WP_001735764.1 PTS N-acetylgalactosamine transporter subunit IIB -
CXW72_RS02595 530337..531116 + 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CXW72_RS02600 531106..531984 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CXW72_RS02605 532002..532436 + 435 WP_000948842.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 517618..527437 9819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T92406 WP_000347273.1 NZ_CP025913:526973-527437 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T92406 NZ_CP025913:526973-527437 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.91 Da        Isoelectric Point: 4.8616

>AT92406 WP_005762317.1 NZ_CP025913:526638-526973 [Escherichia coli]
MPANARSHAVLTSESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT92406 NZ_CP025913:526638-526973 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCTCTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References