269720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2420623..2421422 Replicon chromosome
Accession NZ_CP117001
Organism Escherichia coli strain MLI108K2

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag NL410_RS13735 Protein ID WP_000347275.1
Coordinates 2420958..2421422 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NL410_RS13730 Protein ID WP_001307405.1
Coordinates 2420623..2420958 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL410_RS13715 (2416408) 2416408..2417178 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NL410_RS13720 (2417194) 2417194..2418528 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NL410_RS13725 (2418903) 2418903..2420474 + 1572 WP_001273752.1 galactarate dehydratase -
NL410_RS13730 (2420623) 2420623..2420958 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NL410_RS13735 (2420958) 2420958..2421422 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NL410_RS13740 (2421477) 2421477..2422286 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NL410_RS13745 (2422535) 2422535..2423815 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NL410_RS13750 (2423838) 2423838..2424311 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NL410_RS13755 (2424322) 2424322..2425101 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
NL410_RS13760 (2425091) 2425091..2425969 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NL410_RS13765 (2425987) 2425987..2426421 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2411475..2421422 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T269720 WP_000347275.1 NZ_CP117001:2420958-2421422 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT269720 WP_001307405.1 NZ_CP117001:2420623-2420958 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References