267641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 629677..630476 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PGH49_RS03050 Protein ID WP_000347275.1
Coordinates 629677..630141 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PGH49_RS03055 Protein ID WP_001307405.1
Coordinates 630141..630476 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS03020 (624678) 624678..625112 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PGH49_RS03025 (625130) 625130..626008 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PGH49_RS03030 (625998) 625998..626777 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PGH49_RS03035 (626788) 626788..627261 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PGH49_RS03040 (627284) 627284..628564 - 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
PGH49_RS03045 (628813) 628813..629622 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PGH49_RS03050 (629677) 629677..630141 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PGH49_RS03055 (630141) 630141..630476 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PGH49_RS03060 (630625) 630625..632196 - 1572 WP_001273752.1 galactarate dehydratase -
PGH49_RS03065 (632571) 632571..633905 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PGH49_RS03070 (633921) 633921..634691 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 629677..641351 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T267641 WP_000347275.1 NZ_CP116035:c630141-629677 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267641 WP_001307405.1 NZ_CP116035:c630476-630141 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References