267979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4078560..4079359 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PIB67_RS19870 Protein ID WP_000347275.1
Coordinates 4078895..4079359 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIB67_RS19865 Protein ID WP_001307405.1
Coordinates 4078560..4078895 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS19850 (4074345) 4074345..4075115 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
PIB67_RS19855 (4075131) 4075131..4076465 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIB67_RS19860 (4076840) 4076840..4078411 + 1572 WP_001273752.1 galactarate dehydratase -
PIB67_RS19865 (4078560) 4078560..4078895 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIB67_RS19870 (4078895) 4078895..4079359 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIB67_RS19875 (4079414) 4079414..4080223 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIB67_RS19880 (4080472) 4080472..4081752 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIB67_RS19885 (4081775) 4081775..4082248 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIB67_RS19890 (4082259) 4082259..4083038 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIB67_RS19895 (4083028) 4083028..4083906 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIB67_RS19900 (4083924) 4083924..4084358 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4069412..4079359 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T267979 WP_000347275.1 NZ_CP116103:4078895-4079359 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267979 WP_001307405.1 NZ_CP116103:4078560-4078895 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References