256930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2102219..2103018 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag NZD79_RS10270 Protein ID WP_000347275.1
Coordinates 2102554..2103018 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NZD79_RS10265 Protein ID WP_001307405.1
Coordinates 2102219..2102554 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS10250 (2098004) 2098004..2098774 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NZD79_RS10255 (2098790) 2098790..2100124 - 1335 WP_259568217.1 galactarate/glucarate/glycerate transporter GarP -
NZD79_RS10260 (2100499) 2100499..2102070 + 1572 WP_001273753.1 galactarate dehydratase -
NZD79_RS10265 (2102219) 2102219..2102554 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NZD79_RS10270 (2102554) 2102554..2103018 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NZD79_RS10275 (2103073) 2103073..2103882 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NZD79_RS10280 (2104131) 2104131..2105411 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NZD79_RS10285 (2105434) 2105434..2105907 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NZD79_RS10290 (2105918) 2105918..2106697 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
NZD79_RS10295 (2106743) 2106743..2107042 + 300 Protein_2019 amidohydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2093119..2103018 9899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T256930 WP_000347275.1 NZ_CP103972:2102554-2103018 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT256930 WP_001307405.1 NZ_CP103972:2102219-2102554 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References