290920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2033800..2034599 Replicon chromosome
Accession NZ_LR890410
Organism Escherichia coli isolate MSB2_1A-sc-2280429

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag JMW04_RS09660 Protein ID WP_000347275.1
Coordinates 2034135..2034599 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JMW04_RS09655 Protein ID WP_001307405.1
Coordinates 2033800..2034135 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW04_RS09640 2029585..2030355 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
JMW04_RS09645 2030371..2031705 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JMW04_RS09650 2032080..2033651 + 1572 WP_001273752.1 galactarate dehydratase -
JMW04_RS09655 2033800..2034135 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW04_RS09660 2034135..2034599 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW04_RS09665 2034654..2035463 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW04_RS09670 2035712..2036992 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW04_RS09675 2037015..2037488 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW04_RS09680 2037499..2038278 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW04_RS09685 2038268..2039146 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW04_RS09690 2039164..2039598 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2024652..2034599 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T290920 WP_000347275.1 NZ_LR890410:2034135-2034599 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT290920 WP_001307405.1 NZ_LR890410:2033800-2034135 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References