259173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3501515..3502314 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N6H17_RS17255 Protein ID WP_000347273.1
Coordinates 3501850..3502314 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N6H17_RS17250 Protein ID WP_001307405.1
Coordinates 3501515..3501850 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS17235 (3497300) 3497300..3498070 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
N6H17_RS17240 (3498086) 3498086..3499420 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N6H17_RS17245 (3499795) 3499795..3501366 + 1572 WP_001273753.1 galactarate dehydratase -
N6H17_RS17250 (3501515) 3501515..3501850 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N6H17_RS17255 (3501850) 3501850..3502314 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N6H17_RS17260 (3502369) 3502369..3503178 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N6H17_RS17265 (3503427) 3503427..3504707 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
N6H17_RS17270 (3504730) 3504730..3505203 + 474 WP_001422480.1 PTS N-acetylgalactosamine transporter subunit IIB -
N6H17_RS17275 (3505214) 3505214..3505993 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
N6H17_RS17280 (3505983) 3505983..3506861 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N6H17_RS17285 (3506879) 3506879..3507313 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3492367..3502314 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T259173 WP_000347273.1 NZ_CP104788:3501850-3502314 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT259173 WP_001307405.1 NZ_CP104788:3501515-3501850 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References