264386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605769..606568 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OQ464_RS02945 Protein ID WP_000347273.1
Coordinates 605769..606233 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OQ464_RS02950 Protein ID WP_001307405.1
Coordinates 606233..606568 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS02920 (601945) 601945..602502 - 558 Protein_572 amidohydrolase family protein -
OQ464_RS02925 (602498) 602498..602869 - 372 Protein_573 PTS sugar transporter subunit IIC -
OQ464_RS02930 (602880) 602880..603353 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
OQ464_RS02935 (603376) 603376..604656 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OQ464_RS02940 (604905) 604905..605714 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OQ464_RS02945 (605769) 605769..606233 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OQ464_RS02950 (606233) 606233..606568 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OQ464_RS02955 (606717) 606717..608288 - 1572 WP_001273753.1 galactarate dehydratase -
OQ464_RS02960 (608663) 608663..609997 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OQ464_RS02965 (610013) 610013..610783 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 605769..617443 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T264386 WP_000347273.1 NZ_CP110859:c606233-605769 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT264386 WP_001307405.1 NZ_CP110859:c606568-606233 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References