268202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 611449..612248 Replicon chromosome
Accession NZ_CP116159
Organism Escherichia coli strain DETEC-P351

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PIC26_RS02985 Protein ID WP_000347275.1
Coordinates 611449..611913 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIC26_RS02990 Protein ID WP_001307405.1
Coordinates 611913..612248 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC26_RS02955 (606450) 606450..606884 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PIC26_RS02960 (606902) 606902..607780 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC26_RS02965 (607770) 607770..608549 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC26_RS02970 (608560) 608560..609033 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC26_RS02975 (609056) 609056..610336 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC26_RS02980 (610585) 610585..611394 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIC26_RS02985 (611449) 611449..611913 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC26_RS02990 (611913) 611913..612248 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC26_RS02995 (612397) 612397..613968 - 1572 WP_001273752.1 galactarate dehydratase -
PIC26_RS03000 (614343) 614343..615677 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIC26_RS03005 (615693) 615693..616463 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 611449..623123 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T268202 WP_000347275.1 NZ_CP116159:c611913-611449 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268202 WP_001307405.1 NZ_CP116159:c612248-611913 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References