267015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3929278..3930077 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag O6106_RS19290 Protein ID WP_000347273.1
Coordinates 3929613..3930077 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag O6106_RS19285 Protein ID WP_001307405.1
Coordinates 3929278..3929613 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS19270 (3925063) 3925063..3925833 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
O6106_RS19275 (3925849) 3925849..3927183 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
O6106_RS19280 (3927558) 3927558..3929129 + 1572 WP_001273753.1 galactarate dehydratase -
O6106_RS19285 (3929278) 3929278..3929613 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
O6106_RS19290 (3929613) 3929613..3930077 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
O6106_RS19295 (3930132) 3930132..3930941 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
O6106_RS19300 (3931190) 3931190..3932470 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
O6106_RS19305 (3932493) 3932493..3932966 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
O6106_RS19310 (3932977) 3932977..3933348 + 372 Protein_3750 PTS sugar transporter subunit IIC -
O6106_RS19315 (3933344) 3933344..3933901 + 558 Protein_3751 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3920130..3930077 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T267015 WP_000347273.1 NZ_CP114895:3929613-3930077 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267015 WP_001307405.1 NZ_CP114895:3929278-3929613 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References