176664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 617667..618466 Replicon chromosome
Accession NZ_CP062815
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag IMQ58_RS02990 Protein ID WP_000347273.1
Coordinates 617667..618131 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IMQ58_RS02995 Protein ID WP_001307405.1
Coordinates 618131..618466 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS02960 612668..613102 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IMQ58_RS02965 613120..613998 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IMQ58_RS02970 613988..614767 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMQ58_RS02975 614778..615251 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMQ58_RS02980 615274..616554 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMQ58_RS02985 616803..617612 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IMQ58_RS02990 617667..618131 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMQ58_RS02995 618131..618466 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMQ58_RS03000 618615..620186 - 1572 WP_001273753.1 galactarate dehydratase -
IMQ58_RS03005 620561..621895 + 1335 WP_095885843.1 galactarate/glucarate/glycerate transporter GarP -
IMQ58_RS03010 621911..622681 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 617667..629341 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T176664 WP_000347273.1 NZ_CP062815:c618131-617667 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T176664 NZ_CP082885:652684-653016 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT176664 WP_001307405.1 NZ_CP062815:c618466-618131 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT176664 NZ_CP082885:653124-653351 [Bartonella henselae]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGCATAGAGGAAGCAGAGGATTATTATTTAGCCTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References