272508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3247218..3248017 Replicon chromosome
Accession NZ_CP117959
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PT284_RS16550 Protein ID WP_000347275.1
Coordinates 3247553..3248017 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PT284_RS16545 Protein ID WP_001307405.1
Coordinates 3247218..3247553 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS16530 (3243003) 3243003..3243773 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
PT284_RS16535 (3243789) 3243789..3245123 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PT284_RS16540 (3245498) 3245498..3247069 + 1572 WP_001273753.1 galactarate dehydratase -
PT284_RS16545 (3247218) 3247218..3247553 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PT284_RS16550 (3247553) 3247553..3248017 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PT284_RS16555 (3248072) 3248072..3248881 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PT284_RS16560 (3249130) 3249130..3250410 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PT284_RS16565 (3250433) 3250433..3250906 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PT284_RS16570 (3250917) 3250917..3251696 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PT284_RS16575 (3251686) 3251686..3252564 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PT284_RS16580 (3252582) 3252582..3253016 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3238070..3248017 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T272508 WP_000347275.1 NZ_CP117959:3247553-3248017 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT272508 WP_001307405.1 NZ_CP117959:3247218-3247553 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References