Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1597522..1598321 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag LXF06_RS07625 Protein ID WP_241415748.1
Coordinates 1597522..1597986 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0TI39
Locus tag LXF06_RS07630 Protein ID WP_021547164.1
Coordinates 1597986..1598321 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS07595 (1592523) 1592523..1592957 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LXF06_RS07600 (1592975) 1592975..1593853 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
LXF06_RS07605 (1593843) 1593843..1594622 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LXF06_RS07610 (1594633) 1594633..1595106 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LXF06_RS07615 (1595129) 1595129..1596409 - 1281 WP_088474653.1 tagatose-bisphosphate aldolase subunit KbaZ -
LXF06_RS07620 (1596658) 1596658..1597467 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LXF06_RS07625 (1597522) 1597522..1597986 - 465 WP_241415748.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LXF06_RS07630 (1597986) 1597986..1598321 - 336 WP_021547164.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LXF06_RS07635 (1598470) 1598470..1600041 - 1572 WP_241415749.1 galactarate dehydratase -
LXF06_RS07640 (1600416) 1600416..1601750 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LXF06_RS07645 (1601766) 1601766..1602536 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1597522..1609196 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17846.29 Da        Isoelectric Point: 9.6924

>T230398 WP_241415748.1 NZ_CP090305:c1597986-1597522 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSPPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T230398 NZ_CP124889:360535-360678 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12309.86 Da        Isoelectric Point: 4.5392

>AT230398 WP_021547164.1 NZ_CP090305:c1598321-1597986 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT230398 NZ_CP124889:c360798-360611 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0TI39

References