262732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3374114..3374913 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OLR76_RS16615 Protein ID WP_000347273.1
Coordinates 3374449..3374913 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OLR76_RS16610 Protein ID WP_001307405.1
Coordinates 3374114..3374449 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS16595 (3369899) 3369899..3370669 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
OLR76_RS16600 (3370685) 3370685..3372019 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OLR76_RS16605 (3372394) 3372394..3373965 + 1572 WP_001273753.1 galactarate dehydratase -
OLR76_RS16610 (3374114) 3374114..3374449 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OLR76_RS16615 (3374449) 3374449..3374913 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OLR76_RS16620 (3374968) 3374968..3375777 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OLR76_RS16625 (3376026) 3376026..3377306 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OLR76_RS16630 (3377329) 3377329..3377802 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
OLR76_RS16635 (3377813) 3377813..3378184 + 372 Protein_3250 PTS sugar transporter subunit IIC -
OLR76_RS16640 (3378180) 3378180..3378737 + 558 Protein_3251 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3364966..3374913 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T262732 WP_000347273.1 NZ_CP110017:3374449-3374913 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT262732 WP_001307405.1 NZ_CP110017:3374114-3374449 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References