257215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3897884..3898683 Replicon chromosome
Accession NZ_CP104112
Organism Escherichia coli strain USDA-ARS-USMARC-51688

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag N1707_RS19060 Protein ID WP_000347251.1
Coordinates 3898219..3898683 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N1707_RS19055 Protein ID WP_001307405.1
Coordinates 3897884..3898219 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1707_RS19040 (3893669) 3893669..3894439 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
N1707_RS19045 (3894455) 3894455..3895789 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N1707_RS19050 (3896164) 3896164..3897735 + 1572 WP_001273753.1 galactarate dehydratase -
N1707_RS19055 (3897884) 3897884..3898219 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N1707_RS19060 (3898219) 3898219..3898683 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N1707_RS19065 (3898738) 3898738..3899547 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N1707_RS19070 (3899796) 3899796..3901076 + 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
N1707_RS19075 (3901099) 3901099..3901572 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N1707_RS19080 (3901583) 3901583..3902362 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N1707_RS19085 (3902352) 3902352..3903230 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N1707_RS19090 (3903248) 3903248..3903682 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3887114..3898683 11569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T257215 WP_000347251.1 NZ_CP104112:3898219-3898683 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT257215 WP_001307405.1 NZ_CP104112:3897884-3898219 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References