268408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4078688..4079487 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PIB63_RS19885 Protein ID WP_000347275.1
Coordinates 4079023..4079487 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIB63_RS19880 Protein ID WP_001307405.1
Coordinates 4078688..4079023 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS19865 (4074473) 4074473..4075243 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
PIB63_RS19870 (4075259) 4075259..4076593 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIB63_RS19875 (4076968) 4076968..4078539 + 1572 WP_001273752.1 galactarate dehydratase -
PIB63_RS19880 (4078688) 4078688..4079023 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIB63_RS19885 (4079023) 4079023..4079487 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIB63_RS19890 (4079542) 4079542..4080351 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIB63_RS19895 (4080600) 4080600..4081880 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIB63_RS19900 (4081903) 4081903..4082376 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIB63_RS19905 (4082387) 4082387..4083166 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIB63_RS19910 (4083156) 4083156..4084034 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIB63_RS19915 (4084052) 4084052..4084486 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4069540..4079487 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T268408 WP_000347275.1 NZ_CP116194:4079023-4079487 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268408 WP_001307405.1 NZ_CP116194:4078688-4079023 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References