276701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1782496..1783295 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QCG49_RS08640 Protein ID WP_000347273.1
Coordinates 1782831..1783295 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QCG49_RS08635 Protein ID WP_001307405.1
Coordinates 1782496..1782831 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS08620 (1778281) 1778281..1779051 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
QCG49_RS08625 (1779067) 1779067..1780401 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QCG49_RS08630 (1780776) 1780776..1782347 + 1572 WP_001273753.1 galactarate dehydratase -
QCG49_RS08635 (1782496) 1782496..1782831 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QCG49_RS08640 (1782831) 1782831..1783295 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QCG49_RS08645 (1783350) 1783350..1784159 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QCG49_RS08650 (1784408) 1784408..1785688 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QCG49_RS08655 (1785711) 1785711..1786184 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QCG49_RS08660 (1786195) 1786195..1786566 + 372 Protein_1693 PTS sugar transporter subunit IIC -
QCG49_RS08665 (1786562) 1786562..1787119 + 558 Protein_1694 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1773348..1783295 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T276701 WP_000347273.1 NZ_CP122317:1782831-1783295 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT276701 WP_001307405.1 NZ_CP122317:1782496-1782831 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References