291545

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 673392..674191 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JMW69_RS03280 Protein ID WP_000347273.1
Coordinates 673392..673856 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JMW69_RS03285 Protein ID WP_001307405.1
Coordinates 673856..674191 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS03250 668393..668827 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JMW69_RS03255 668845..669723 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW69_RS03260 669713..670492 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW69_RS03265 670503..670976 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW69_RS03270 670999..672279 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW69_RS03275 672528..673337 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW69_RS03280 673392..673856 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW69_RS03285 673856..674191 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW69_RS03290 674340..675911 - 1572 WP_069905074.1 galactarate dehydratase -
JMW69_RS03295 676286..677620 + 1335 WP_069905075.1 galactarate/glucarate/glycerate transporter GarP -
JMW69_RS03300 677636..678406 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 673392..685066 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T291545 WP_000347273.1 NZ_LR890606:c673856-673392 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT291545 WP_001307405.1 NZ_LR890606:c674191-673856 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References