253554

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3146770..3147569 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NR350_RS15305 Protein ID WP_000347273.1
Coordinates 3147105..3147569 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NR350_RS15300 Protein ID WP_001307405.1
Coordinates 3146770..3147105 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS15285 (3142555) 3142555..3143325 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NR350_RS15290 (3143341) 3143341..3144675 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NR350_RS15295 (3145050) 3145050..3146621 + 1572 WP_001273753.1 galactarate dehydratase -
NR350_RS15300 (3146770) 3146770..3147105 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NR350_RS15305 (3147105) 3147105..3147569 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NR350_RS15310 (3147624) 3147624..3148433 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NR350_RS15315 (3148682) 3148682..3149962 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NR350_RS15320 (3149985) 3149985..3150458 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NR350_RS15325 (3150469) 3150469..3150840 + 372 Protein_2990 PTS sugar transporter subunit IIC -
NR350_RS15330 (3150836) 3150836..3151393 + 558 Protein_2991 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3137622..3147569 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T253554 WP_000347273.1 NZ_CP102379:3147105-3147569 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT253554 WP_001307405.1 NZ_CP102379:3146770-3147105 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References