276753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1079938..1080737 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QCG47_RS05125 Protein ID WP_000347273.1
Coordinates 1080273..1080737 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QCG47_RS05120 Protein ID WP_001307405.1
Coordinates 1079938..1080273 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS05105 (1075723) 1075723..1076493 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
QCG47_RS05110 (1076509) 1076509..1077843 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QCG47_RS05115 (1078218) 1078218..1079789 + 1572 WP_001273753.1 galactarate dehydratase -
QCG47_RS05120 (1079938) 1079938..1080273 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QCG47_RS05125 (1080273) 1080273..1080737 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QCG47_RS05130 (1080792) 1080792..1081601 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QCG47_RS05135 (1081850) 1081850..1083130 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QCG47_RS05140 (1083153) 1083153..1083626 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QCG47_RS05145 (1083637) 1083637..1084008 + 372 Protein_1001 PTS sugar transporter subunit IIC -
QCG47_RS05150 (1084004) 1084004..1084561 + 558 Protein_1002 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1070790..1080737 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T276753 WP_000347273.1 NZ_CP122319:1080273-1080737 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT276753 WP_001307405.1 NZ_CP122319:1079938-1080273 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References