141609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 618542..619341 Replicon chromosome
Accession NZ_CP045277
Organism Escherichia coli strain LAU-OXA

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag GBF15_RS03005 Protein ID WP_000347273.1
Coordinates 618542..619006 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag GBF15_RS03010 Protein ID WP_001307405.1
Coordinates 619006..619341 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBF15_RS02975 613543..613977 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
GBF15_RS02980 613995..614873 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
GBF15_RS02985 614863..615642 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
GBF15_RS02990 615653..616126 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
GBF15_RS02995 616149..617429 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
GBF15_RS03000 617678..618487 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
GBF15_RS03005 618542..619006 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
GBF15_RS03010 619006..619341 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
GBF15_RS03015 619490..621061 - 1572 WP_069905074.1 galactarate dehydratase -
GBF15_RS03020 621436..622770 + 1335 WP_069905075.1 galactarate/glucarate/glycerate transporter GarP -
GBF15_RS03025 622786..623556 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 618542..630216 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T141609 WP_000347273.1 NZ_CP045277:c619006-618542 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T141609 NZ_CP060040:1905741-1906112 [Burkholderia cenocepacia]
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGCCGGCGACGCGACGCTCACCGCATTGCTGGAAGCGGA
GCGAGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCACAATCGCGAGACCGTGCTAGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTCCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT141609 WP_001307405.1 NZ_CP045277:c619341-619006 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT141609 NZ_CP060040:1905547-1905744 [Burkholderia cenocepacia]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCTGATC
TTGAATCGGTCCCACGCCGCCCGTCGGAGCTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References