212526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2064262..2065061 Replicon chromosome
Accession NZ_CP081009
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag K3830_RS09810 Protein ID WP_000347273.1
Coordinates 2064597..2065061 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag K3830_RS09805 Protein ID WP_001307405.1
Coordinates 2064262..2064597 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3830_RS09790 (2060047) 2060047..2060817 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
K3830_RS09795 (2060833) 2060833..2062167 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
K3830_RS09800 (2062542) 2062542..2064113 + 1572 WP_001273747.1 galactarate dehydratase -
K3830_RS09805 (2064262) 2064262..2064597 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
K3830_RS09810 (2064597) 2064597..2065061 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
K3830_RS09815 (2065116) 2065116..2065925 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
K3830_RS09820 (2066174) 2066174..2067454 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
K3830_RS09825 (2067477) 2067477..2067950 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
K3830_RS09830 (2067961) 2067961..2068332 + 372 Protein_1937 PTS sugar transporter subunit IIC -
K3830_RS09835 (2068328) 2068328..2068885 + 558 Protein_1938 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2050346..2065061 14715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T212526 WP_000347273.1 NZ_CP081009:2064597-2065061 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T212526 NZ_CP107247:1869690-1869965 [Coxiella burnetii]
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT212526 WP_001307405.1 NZ_CP081009:2064262-2064597 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT212526 NZ_CP107247:1869436-1869690 [Coxiella burnetii]
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References