80995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 629844..630643 Replicon chromosome
Accession NZ_CP023371
Organism Escherichia coli strain 1283

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag CNQ51_RS03310 Protein ID WP_000347275.1
Coordinates 629844..630308 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag CNQ51_RS03315 Protein ID WP_001307405.1
Coordinates 630308..630643 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ51_RS03275 624845..625279 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
CNQ51_RS03280 625297..626175 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CNQ51_RS03285 626165..626944 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CNQ51_RS03290 626955..627428 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
CNQ51_RS03295 627451..628731 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
CNQ51_RS03305 628980..629789 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
CNQ51_RS03310 629844..630308 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CNQ51_RS03315 630308..630643 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CNQ51_RS03320 630792..632363 - 1572 WP_001273752.1 galactarate dehydratase -
CNQ51_RS03325 632738..634072 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
CNQ51_RS03330 634088..634858 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 629844..641518 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T80995 WP_000347275.1 NZ_CP023371:c630308-629844 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T80995 NZ_CP023371:c630308-629844 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT80995 WP_001307405.1 NZ_CP023371:c630643-630308 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT80995 NZ_CP023371:c630643-630308 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References