266982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2639944..2640743 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag O6X69_RS12985 Protein ID WP_000347273.1
Coordinates 2640279..2640743 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag O6X69_RS12980 Protein ID WP_001307405.1
Coordinates 2639944..2640279 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS12965 (2635729) 2635729..2636499 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
O6X69_RS12970 (2636515) 2636515..2637849 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
O6X69_RS12975 (2638224) 2638224..2639795 + 1572 WP_001273753.1 galactarate dehydratase -
O6X69_RS12980 (2639944) 2639944..2640279 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
O6X69_RS12985 (2640279) 2640279..2640743 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
O6X69_RS12990 (2640798) 2640798..2641607 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
O6X69_RS12995 (2641856) 2641856..2643136 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
O6X69_RS13000 (2643159) 2643159..2643632 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
O6X69_RS13005 (2643643) 2643643..2644014 + 372 Protein_2534 PTS sugar transporter subunit IIC -
O6X69_RS13010 (2644010) 2644010..2644567 + 558 Protein_2535 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2630796..2640743 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T266982 WP_000347273.1 NZ_CP114894:2640279-2640743 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT266982 WP_001307405.1 NZ_CP114894:2639944-2640279 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References