277438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 622498..623297 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDW62_RS03055 Protein ID WP_000347273.1
Coordinates 622498..622962 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW62_RS03060 Protein ID WP_001307405.1
Coordinates 622962..623297 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS03025 (617499) 617499..617933 - 435 WP_000948814.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW62_RS03030 (617951) 617951..618829 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW62_RS03035 (618819) 618819..619598 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW62_RS03040 (619609) 619609..620082 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW62_RS03045 (620105) 620105..621385 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW62_RS03050 (621634) 621634..622443 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDW62_RS03055 (622498) 622498..622962 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW62_RS03060 (622962) 622962..623297 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW62_RS03065 (623446) 623446..625017 - 1572 WP_001273754.1 galactarate dehydratase -
QDW62_RS03070 (625392) 625392..626726 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDW62_RS03075 (626742) 626742..627512 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 622498..634059 11561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277438 WP_000347273.1 NZ_CP122634:c622962-622498 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277438 WP_001307405.1 NZ_CP122634:c623297-622962 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References