253588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3148106..3148905 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NR349_RS15300 Protein ID WP_000347273.1
Coordinates 3148441..3148905 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NR349_RS15295 Protein ID WP_001307405.1
Coordinates 3148106..3148441 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS15280 (3143891) 3143891..3144661 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
NR349_RS15285 (3144677) 3144677..3146011 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NR349_RS15290 (3146386) 3146386..3147957 + 1572 WP_001273753.1 galactarate dehydratase -
NR349_RS15295 (3148106) 3148106..3148441 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NR349_RS15300 (3148441) 3148441..3148905 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NR349_RS15305 (3148960) 3148960..3149769 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NR349_RS15310 (3150018) 3150018..3151298 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NR349_RS15315 (3151321) 3151321..3151794 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NR349_RS15320 (3151805) 3151805..3152176 + 372 Protein_2989 PTS sugar transporter subunit IIC -
NR349_RS15325 (3152172) 3152172..3152729 + 558 Protein_2990 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3138958..3148905 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T253588 WP_000347273.1 NZ_CP102380:3148441-3148905 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT253588 WP_001307405.1 NZ_CP102380:3148106-3148441 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References