157674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3702832..3703631 Replicon chromosome
Accession NZ_CP053736
Organism Escherichia coli strain CP8-3_Sichuan

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag HP430_RS17840 Protein ID WP_000347273.1
Coordinates 3703167..3703631 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HP430_RS17835 Protein ID WP_001307405.1
Coordinates 3702832..3703167 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP430_RS17820 3698617..3699387 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
HP430_RS17825 3699403..3700737 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HP430_RS17830 3701112..3702683 + 1572 WP_001273753.1 galactarate dehydratase -
HP430_RS17835 3702832..3703167 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HP430_RS17840 3703167..3703631 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HP430_RS17845 3703686..3704495 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HP430_RS17850 3704744..3706024 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
HP430_RS17855 3706047..3706520 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
HP430_RS17860 3706531..3707310 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HP430_RS17865 3707300..3708178 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HP430_RS17870 3708196..3708630 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3693684..3703631 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T157674 WP_000347273.1 NZ_CP053736:3703167-3703631 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T157674 NZ_CP069445:c3196026-3195919 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT157674 WP_001307405.1 NZ_CP053736:3702832-3703167 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT157674 NZ_CP069445:3196083-3196138 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References