272590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 953782..954581 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag PT723_RS04600 Protein ID WP_000347273.1
Coordinates 953782..954246 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PT723_RS04605 Protein ID WP_001307405.1
Coordinates 954246..954581 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS04570 (948783) 948783..949217 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PT723_RS04575 (949235) 949235..950113 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PT723_RS04580 (950103) 950103..950882 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PT723_RS04585 (950893) 950893..951366 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PT723_RS04590 (951389) 951389..952669 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PT723_RS04595 (952918) 952918..953727 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PT723_RS04600 (953782) 953782..954246 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PT723_RS04605 (954246) 954246..954581 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PT723_RS04610 (954730) 954730..956301 - 1572 WP_137044537.1 galactarate dehydratase -
PT723_RS04615 (956676) 956676..958010 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PT723_RS04620 (958026) 958026..958796 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 953782..965456 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T272590 WP_000347273.1 NZ_CP117971:c954246-953782 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT272590 WP_001307405.1 NZ_CP117971:c954581-954246 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References