150388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 587910..588709 Replicon chromosome
Accession NZ_CP049081
Organism Escherichia coli strain p10A

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag G6P90_RS02870 Protein ID WP_000347275.1
Coordinates 587910..588374 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag G6P90_RS02875 Protein ID WP_001307405.1
Coordinates 588374..588709 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P90_RS02840 582911..583345 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
G6P90_RS02845 583363..584241 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
G6P90_RS02850 584231..585010 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
G6P90_RS02855 585021..585494 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
G6P90_RS02860 585517..586797 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
G6P90_RS02865 587046..587855 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
G6P90_RS02870 587910..588374 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
G6P90_RS02875 588374..588709 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
G6P90_RS02880 588858..590429 - 1572 WP_001273752.1 galactarate dehydratase -
G6P90_RS02885 590804..592138 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
G6P90_RS02890 592154..592924 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 587910..599584 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T150388 WP_000347275.1 NZ_CP049081:c588374-587910 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T150388 NZ_CP064680:c475764-475546 [Escherichia coli K-12]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT150388 WP_001307405.1 NZ_CP049081:c588709-588374 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT150388 NZ_CP064680:c476164-475790 [Escherichia coli K-12]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References