278202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 658675..659474 Replicon chromosome
Accession NZ_CP122923
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX14_RS03160 Protein ID WP_000347273.1
Coordinates 658675..659139 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX14_RS03165 Protein ID WP_001307405.1
Coordinates 659139..659474 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS03130 (653676) 653676..654110 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX14_RS03135 (654128) 654128..655006 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX14_RS03140 (654996) 654996..655775 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX14_RS03145 (655786) 655786..656259 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX14_RS03150 (656282) 656282..657562 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX14_RS03155 (657811) 657811..658620 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX14_RS03160 (658675) 658675..659139 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX14_RS03165 (659139) 659139..659474 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX14_RS03170 (659623) 659623..661194 - 1572 WP_094336530.1 galactarate dehydratase -
QDX14_RS03175 (661569) 661569..662903 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX14_RS03180 (662919) 662919..663689 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 658675..670348 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278202 WP_000347273.1 NZ_CP122923:c659139-658675 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278202 WP_001307405.1 NZ_CP122923:c659474-659139 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References