278134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 664031..664830 Replicon chromosome
Accession NZ_CP122872
Organism Escherichia coli strain ETEC1718

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX06_RS03190 Protein ID WP_000347273.1
Coordinates 664031..664495 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX06_RS03195 Protein ID WP_001307405.1
Coordinates 664495..664830 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX06_RS03160 (659032) 659032..659466 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX06_RS03165 (659484) 659484..660362 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX06_RS03170 (660352) 660352..661131 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX06_RS03175 (661142) 661142..661615 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX06_RS03180 (661638) 661638..662918 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX06_RS03185 (663167) 663167..663976 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX06_RS03190 (664031) 664031..664495 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX06_RS03195 (664495) 664495..664830 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX06_RS03200 (664979) 664979..666550 - 1572 WP_094336530.1 galactarate dehydratase -
QDX06_RS03205 (666925) 666925..668259 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX06_RS03210 (668275) 668275..669045 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 664031..675703 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278134 WP_000347273.1 NZ_CP122872:c664495-664031 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278134 WP_001307405.1 NZ_CP122872:c664830-664495 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References