287466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606059..606858 Replicon chromosome
Accession NZ_LR134295
Organism Escherichia coli strain NCTC9080

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag EL145_RS02930 Protein ID WP_000347273.1
Coordinates 606059..606523 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0K5UM65
Locus tag EL145_RS02935 Protein ID WP_025670440.1
Coordinates 606523..606858 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL145_RS02900 601060..601494 - 435 WP_000948814.1 PTS sugar transporter subunit IIA -
EL145_RS02905 601512..602390 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL145_RS02910 602380..603159 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL145_RS02915 603170..603643 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL145_RS02920 603666..604946 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL145_RS02925 605195..606004 + 810 WP_126327469.1 aga operon transcriptional regulator AgaR -
EL145_RS02930 606059..606523 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL145_RS02935 606523..606858 - 336 WP_025670440.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL145_RS02940 607007..608578 - 1572 WP_032202412.1 galactarate dehydratase -
EL145_RS02945 608953..610287 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EL145_RS02950 610303..611073 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 606059..617733 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T287466 WP_000347273.1 NZ_LR134295:c606523-606059 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12387.00 Da        Isoelectric Point: 5.1498

>AT287466 WP_025670440.1 NZ_LR134295:c606858-606523 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PRKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0K5UM65

References