156442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4973494..4974293 Replicon chromosome
Accession NZ_CP053251
Organism Escherichia coli strain SCU-204

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag HHJ42_RS24045 Protein ID WP_000347275.1
Coordinates 4973829..4974293 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HHJ42_RS24040 Protein ID WP_001307405.1
Coordinates 4973494..4973829 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ42_RS24025 4969278..4970048 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
HHJ42_RS24030 4970064..4971398 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HHJ42_RS24035 4971773..4973344 + 1572 WP_001273752.1 galactarate dehydratase -
HHJ42_RS24040 4973494..4973829 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HHJ42_RS24045 4973829..4974293 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HHJ42_RS24050 4974348..4975157 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HHJ42_RS24055 4975406..4976686 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
HHJ42_RS24060 4976709..4977182 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
HHJ42_RS24065 4977193..4977972 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HHJ42_RS24070 4977962..4978840 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HHJ42_RS24075 4978858..4979292 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4964341..4974293 9952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T156442 WP_000347275.1 NZ_CP053251:4973829-4974293 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T156442 NZ_CP069065:c751334-750951 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT156442 WP_001307405.1 NZ_CP053251:4973494-4973829 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT156442 NZ_CP069065:c751584-751429 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References