288344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 638756..639555 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag E4V11_RS03070 Protein ID WP_000347275.1
Coordinates 638756..639220 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag E4V11_RS03075 Protein ID WP_001307405.1
Coordinates 639220..639555 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS03040 633757..634191 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
E4V11_RS03045 634209..635087 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
E4V11_RS03050 635077..635856 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
E4V11_RS03055 635867..636340 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
E4V11_RS03060 636363..637643 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
E4V11_RS03065 637892..638701 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
E4V11_RS03070 638756..639220 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
E4V11_RS03075 639220..639555 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
E4V11_RS03080 639704..641275 - 1572 WP_001273753.1 galactarate dehydratase -
E4V11_RS03085 641650..642984 + 1335 WP_066008923.1 galactarate/glucarate/glycerate transporter GarP -
E4V11_RS03090 643000..643770 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 638756..650430 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T288344 WP_000347275.1 NZ_LR217818:c639220-638756 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT288344 WP_001307405.1 NZ_LR217818:c639555-639220 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References