266933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2506990..2507789 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag O6Q95_RS12330 Protein ID WP_000347273.1
Coordinates 2507325..2507789 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag O6Q95_RS12325 Protein ID WP_001307405.1
Coordinates 2506990..2507325 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS12310 (2502775) 2502775..2503545 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
O6Q95_RS12315 (2503561) 2503561..2504895 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
O6Q95_RS12320 (2505270) 2505270..2506841 + 1572 WP_001273753.1 galactarate dehydratase -
O6Q95_RS12325 (2506990) 2506990..2507325 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
O6Q95_RS12330 (2507325) 2507325..2507789 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
O6Q95_RS12335 (2507844) 2507844..2508653 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
O6Q95_RS12340 (2508902) 2508902..2510182 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
O6Q95_RS12345 (2510205) 2510205..2510678 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
O6Q95_RS12350 (2510689) 2510689..2511060 + 372 Protein_2418 PTS sugar transporter subunit IIC -
O6Q95_RS12355 (2511056) 2511056..2511613 + 558 Protein_2419 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2497842..2507789 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T266933 WP_000347273.1 NZ_CP114892:2507325-2507789 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT266933 WP_001307405.1 NZ_CP114892:2506990-2507325 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References