177253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 616511..617310 Replicon chromosome
Accession NZ_CP062908
Organism Escherichia coli strain Res13-Lact-EB12-05

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag IMP23_RS04150 Protein ID WP_000347273.1
Coordinates 616511..616975 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IMP23_RS04155 Protein ID WP_001307405.1
Coordinates 616975..617310 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP23_RS04120 611512..611946 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
IMP23_RS04125 611964..612842 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IMP23_RS04130 612832..613611 - 780 WP_195714470.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMP23_RS04135 613622..614095 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMP23_RS04140 614118..615398 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMP23_RS04145 615647..616456 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IMP23_RS04150 616511..616975 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMP23_RS04155 616975..617310 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMP23_RS04160 617459..619030 - 1572 WP_061350518.1 galactarate dehydratase -
IMP23_RS04165 619208..620224 - 1017 WP_001310555.1 IS5-like element IS5 family transposase -
IMP23_RS04170 620604..621938 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 616511..630723 14212
flank IS/Tn - - 619208..620188 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T177253 WP_000347273.1 NZ_CP062908:c616975-616511 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T177253 NZ_CP083371:c1486982-1486476 [Ensifer canadensis]
ATGTCGGAGAGTGAGCCGGTGCGCCTCTGGCGCGCCTATGTGCCCCGCTGGGCCCACGCTCCGCTTTCGGGCGATGGTGC
CGCGCGCTTCGGCGGCCGCTGGAACCCGGTCGGCCTGCCGACGATTTACGCGGCGCGCGAACTGTCGACCGCCTGGGCGG
AATATAACCAGAGCTTTGTCCAGCATCCCGCTTTGATCGCTCAGCTTGAACTGCGGCATGCGTGGCTGGCCGATATGATG
GCGCCGGATGTGCTTGCGGATTTCGGCGTTACTGATGATATCCACCGGGAGGAGTGGCGCGACGCACTGGATCAAGGCGT
GGTGCCGGCGACGCACCGTCTGCAGGCGGAGTTGACCAGCCGTGGTTTCGATGGGCTGATCTACCCGTCCTTCATGTCCC
CGGGCGGCAGCTGCGTCGCGCTCTGGCGATGGAATGCCGGCGGGGCGGAGTTGACGGTGATCGATCCGGAAAGCCGCTTG
CCGAAGACGCCGGCGTCCTGGCTCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT177253 WP_001307405.1 NZ_CP062908:c617310-616975 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT177253 NZ_CP083371:c1487353-1486982 [Ensifer canadensis]
ATGTCAGCCGTCGGCTTCAACATCTCTGCCTCCCATTTCGGCGAAAGCCAGTCGTCGTTTCTGTCTGCCCGGCTGGTCGC
GGATCGTCTGGGCGTGACACTTGCGGAACTGGCGAAGCTGATCGGCGTCGCACGCAACACGCTGACGGCGAAGTCGAGCG
CGCGCAAGGTCGACGCGGCTCTCAGCAAAGTCGTGCGTATCCTCGCCATGGCTGCCGAAATGGCGGGCGACGAGAGCCGG
GCCGTGATCTGGTTCAAGCACCAGCCGATCCCCGGATGGGCGGGCAAGACTGCCTATGATCTTGCCCGAGAGGGCAAGGC
AGACAAGGTGCTTGCCTATCTCGAGGCCGTGCGTTCGGGTGTCTACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References