Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) dinQ-agrB/-
Location 3647705..3648146 Replicon chromosome
Accession NC_000913
Organism Escherichia coli str. K-12 substr. MG1655
T1TAdb ID TA07189

Toxin (Protein)


Gene name dinQ Uniprot ID A5A624
Locus tag b4613 Protein ID YP_001165328.2
Coordinates 3647705..3647788 (-) Length 28 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 3648294..3648377 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
b3498 3643140..3645182 - 2043 NP_417955.1 oligopeptidase A -
b3499 3645385..3646227 + 843 NP_417956.1 23S rRNA m(6)A2030 methyltransferase -
b3500 3646299..3647651 + 1353 NP_417957.1 glutathione reductase (NADPH) -
b4613 3647705..3647788 - 84 YP_001165328.2 membrane toxin DinQ Toxin
- 3648294..3648377 + 84 - - Antitoxin
b3501 3648528..3648881 + 354 NP_417958.1 DNA-binding transcriptional repressor ArsR -
b3502 3648935..3650224 + 1290 NP_417959.4 arsenite/antimonite:H(+) antiporter -
b3503 3650237..3650662 + 426 NP_417960.1 arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3652182..3653162 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 28 a.a.        Molecular weight: 2988.78 Da        Isoelectric Point: 5.9482

>T6364 YP_001165328.2 NC_000913:c3647788-3647705 [Escherichia coli str. K-12 substr. MG1655]
VIDKAIIVLGALIALLELIRFLLQLLN

Download         Length: 84 bp

>T6364 NC_000913:c3647788-3647705 [Escherichia coli str. K-12 substr. MG1655]
GTGATTGATAAAGCAATCATCGTTCTAGGGGCGTTAATTGCGCTGCTGGAACTGATCCGCTTTCTGCTTCAGCTTCTGAA
CTGA

Antitoxin


Download         Length: 84 bp

>AT6364 NC_000913:3648294-3648377 [Escherichia coli str. K-12 substr. MG1655]
TTAGATAAGAACTCTCTCACTCCAGCCAGAGCCACCAACTCAGGGCTGGAAAGTAAAAAACCGACGCAAAGTCGGTTTTT
TTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A5A624

Antitoxin

Download structure file

References

(1) Ragnhild Weel-Sneve et al. (2013) Single transmembrane peptide DinQ modulates membrane-dependent activities. PLoS Genetics 9(2):e1003260. [PubMed:23408903] experimental

(2) Knut I Kristiansen et al. (2016) Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli. RNA (New York, N.Y.) 22(11):1739-1749. [PubMed:27651528] experimental


experimental experimental literature