Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2306047..2306573 Replicon chromosome
Accession NZ_CP062815
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IMQ58_RS11160 Protein ID WP_000323025.1
Coordinates 2306286..2306573 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IMQ58_RS11155 Protein ID WP_000534858.1
Coordinates 2306047..2306286 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS11130 2301381..2301737 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
IMQ58_RS11135 2302348..2302635 + 288 Protein_2176 hypothetical protein -
IMQ58_RS11140 2303404..2304745 + 1342 Protein_2177 ISNCY family transposase -
IMQ58_RS11145 2305182..2305514 - 333 WP_001317460.1 FlxA-like family protein -
IMQ58_RS11150 2305717..2306022 - 306 WP_001326990.1 hypothetical protein -
IMQ58_RS11155 2306047..2306286 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IMQ58_RS11160 2306286..2306573 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IMQ58_RS11165 2306645..2306800 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IMQ58_RS11170 2307017..2307268 + 252 WP_000980994.1 hypothetical protein -
IMQ58_RS11175 2307335..2307613 + 279 WP_012304870.1 hypothetical protein -
IMQ58_RS11180 2307615..2308664 + 1050 WP_001265198.1 DUF968 domain-containing protein -
IMQ58_RS11185 2308678..2309430 + 753 WP_001047135.1 antitermination protein -
IMQ58_RS11190 2309708..2309797 - 90 WP_120795389.1 hypothetical protein -
IMQ58_RS11195 2309852..2310064 - 213 WP_000087756.1 cold shock-like protein CspF -
IMQ58_RS11200 2310334..2311350 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2282498..2324500 42002
flank IS/Tn - - 2310370..2311350 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T176679 WP_000323025.1 NZ_CP062815:2306286-2306573 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T176679 NZ_CP082904:c2455898-2455797 [Mixta hanseatica]
GGCAAGGCGACATCGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTTACAAGAGCCATTTCCCTGGACCGAATATAG
GAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT176679 WP_000534858.1 NZ_CP062815:2306047-2306286 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT176679 NZ_CP082904:2455789-2455898 [Mixta hanseatica]
AACAAGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCCAGGGAAATGGCTCTTGTAAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCGATGTCGCCTTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References