176679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2306047..2306573 Replicon chromosome
Accession NZ_CP062815
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IMQ58_RS11160 Protein ID WP_000323025.1
Coordinates 2306286..2306573 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IMQ58_RS11155 Protein ID WP_000534858.1
Coordinates 2306047..2306286 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS11130 2301381..2301737 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
IMQ58_RS11135 2302348..2302635 + 288 Protein_2176 hypothetical protein -
IMQ58_RS11140 2303404..2304745 + 1342 Protein_2177 ISNCY family transposase -
IMQ58_RS11145 2305182..2305514 - 333 WP_001317460.1 FlxA-like family protein -
IMQ58_RS11150 2305717..2306022 - 306 WP_001326990.1 hypothetical protein -
IMQ58_RS11155 2306047..2306286 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IMQ58_RS11160 2306286..2306573 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IMQ58_RS11165 2306645..2306800 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IMQ58_RS11170 2307017..2307268 + 252 WP_000980994.1 hypothetical protein -
IMQ58_RS11175 2307335..2307613 + 279 WP_012304870.1 hypothetical protein -
IMQ58_RS11180 2307615..2308664 + 1050 WP_001265198.1 DUF968 domain-containing protein -
IMQ58_RS11185 2308678..2309430 + 753 WP_001047135.1 antitermination protein -
IMQ58_RS11190 2309708..2309797 - 90 WP_120795389.1 hypothetical protein -
IMQ58_RS11195 2309852..2310064 - 213 WP_000087756.1 cold shock-like protein CspF -
IMQ58_RS11200 2310334..2311350 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2282498..2324500 42002
flank IS/Tn - - 2310370..2311350 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T176679 WP_000323025.1 NZ_CP062815:2306286-2306573 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T176679 NZ_CP082904:c2455898-2455797 [Mixta hanseatica]
GGCAAGGCGACATCGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTTACAAGAGCCATTTCCCTGGACCGAATATAG
GAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT176679 WP_000534858.1 NZ_CP062815:2306047-2306286 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT176679 NZ_CP082904:2455789-2455898 [Mixta hanseatica]
AACAAGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCCAGGGAAATGGCTCTTGTAAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCGATGTCGCCTTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References